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ARV-471 degrades ERamutants ARV-471 is a potent ERadegrader SABCS, Dec 4-8, 2018 MCF7 / estradiol Summary • Orally-bioavailable ARV-471 demonstrates single-digit nanomolar ERadegradation potency in wild-type and variant ERa-expressing cell lines • ARV-471 displays no agonist activity in rodent uterine tissue
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The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study.
“ARV-471 is our second program in six months to receive IND clearance, and we are pleased to be advancing it into the clinic and progressing Arvinas’ portfolio of PROTAC ® protein degraders
Over 80% of breast cancer patients are ER positive. ARV-471 AACR Presentation . April 11, 2021.
ARV-471 degrades ERamutants ARV-471 is a potent ERadegrader SABCS, Dec 4-8, 2018 MCF7 / estradiol Summary • Orally-bioavailable ARV-471 demonstrates single-digit nanomolar ERadegradation potency in wild-type and variant ERa-expressing cell lines • ARV-471 displays no agonist activity in rodent uterine tissue
This program is currently in a Phase 1 clinical study and is wholly owned by Arvinas. ARV-471 degrades ERamutants ARV-471 is a potent ERadegrader SABCS, Dec 4-8, 2018 MCF7 / estradiol Summary • Orally-bioavailable ARV-471 demonstrates single-digit nanomolar ERadegradation potency in wild-type and variant ERa-expressing cell lines • ARV-471 displays no agonist activity in rodent uterine tissue ARV-110 and ARV471 are two PROTAC molecules developed based on Arvinas’ proprietary technology platform-PROTAC (Proteolysis-Targeted Chimera) protein degradation agent. ARV-110 is the world’s first oral bioavailable PRAOTC small molecule drug that has entered clinical trials in the field of protein degradation targeted chimeras. December 17, 2020 PROTAC News, PROTAC Research ARV-110, ARV-471, estrogen receptor, protac On December 14, 2020, Arvinas released the latest clinical data of ARV-471 and ARV-110, which showed strong therapeutic potential.
April 11, 2021. Arvinas Corporate Presentation – March 2021. March 16, 2021. Clinical Program Update: ARV-471 & ARV-110. December 14, 2020. ARV-471 (undisclosed structure), 11 an estrogen (ER) degrader from Arvinas, Inc., is also in phase 1 studies in women with locally advanced or metastatic ER positive/HER2 negative breast cancer.
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One Wall Street analyst, Mark Breidenbach with Oppenheimer Co., told Yahoo! Finance that the breast cancer drug candidate ARV 471 has “blockbuster potential.” A drug is considered a blockbuster in the pharmaceutical industry if it is generates annual sales of at least $1 billion for the company that sells it.
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ARV-471 is a clinical stage, oral PROTAC ® degrader that targets the estrogen receptor (ER), a highly validated driver of breast cancer. More information is available here.
In this review, we will summarize recent progress of 26 Jan 2021 Clinical trial for breast carcinoma | breast | cancer | Breast Cancer Diagnosis | Breast Cancer , A Phase 1/2 Trial of ARV-471 Alone and in ARV-471: an ER-targeting protein degrader for breast cancer.